CHEMICAL AND BIOCHEMICAL-STUDIES WITH DITHIOATE DNA

被引：25

作者：

CARUTHERS, MH

BEATON, G

CUMMINS, L

DELLINGER, D

GRAFF, D

MA, YX

MARSHALL, WS

SASMOR, H

SHANKLAND, P

WU, JV

YAU, EK

机构：

[1] Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO

来源：

NUCLEOSIDES & NUCLEOTIDES | 1991年 / 10卷 / 1-3期

关键词：

D O I：

10.1080/07328319108046435

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Dithioate DNA was synthesized and used for various biochemical studies. Results from these studies indicate that dithioate DNA is a potent inhibitor of HIV Reverse Transcriptase, activates endogenous RNase H in Hela cell nuclear extracts, and is a useful probe for studying protein-DNA interactions.

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页码：47 / 59

页数：13

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