INHIBITION OF ACETYLCHOLINE OUTFLOW FROM GUINEA-PIG CEREBRAL-CORTEX FOLLOWING LOCUS COERULEUS STIMULATION

被引：26

作者：

BIANCHI, C ^{[1
]}

SPIDALIERI, G ^{[1
]}

GUANDALINI, P ^{[1
]}

TANGANELLI, S ^{[1
]}

BEANI, L ^{[1
]}

机构：

[1] INST HUMAN PHYSIOL,FERRARA,ITALY

来源：

NEUROSCIENCE LETTERS | 1979年 / 14卷 / 01期

关键词：

D O I：

10.1016/0304-3940(79)95351-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Experiments were performed in unanaesthetized guinea-pigs in order to obtain direct evidence that the noradrenergic projections from locus coeruleus (L.C.) to cerebral cortex inhibit the acetylcholine (ACh) release. The animals were provided with left and right epidural cups, to collect outflowing ACh and with a stimulating electrode, positioned in the left L.C. The electrical stimulation of L.C. caused a significant reduction of ACh outflow from both parietal areas. This effect was abolished, reduced or prevented by phentolamine, phenoxybenzamine or reserpine plus α-mt pretreatment, hence showing to be α-mediated. © 1979.

引用

页码：97 / 100

页数：4

共 8 条

[1] NORADRENALINE INHIBITION OF ACETYLCHOLINE-RELEASE FROM GUINEA-PIG BRAIN [J].