A MUTATED INTRON SEQUENCE CODES FOR AN ANTIGENIC PEPTIDE RECOGNIZED BY CYTOLYTIC T-LYMPHOCYTES ON A HUMAN-MELANOMA

被引:363
作者
COULIE, PG [1 ]
LEHMANN, F [1 ]
LETHE, B [1 ]
HERMAN, J [1 ]
LURQUIN, C [1 ]
ANDRAWISS, M [1 ]
BOON, T [1 ]
机构
[1] UNIV CATHOLIQUE LOUVAIN,CELLULAR GENET UNIT,B-1200 BRUSSELS,BELGIUM
关键词
D O I
10.1073/pnas.92.17.7976
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We have identified an antigen recognized on a human melanoma by autologous cytolytic T lymphocytes. It is encoded by a gene that is expressed in many normal tissues. Remarkably, the sequence coding for the antigenic peptide is located across an exon-intron junction. A point mutation is present in the intron that generates an amino acid change that is essential for the recognition of the peptide by the anti-tumor cytotoxic T lymphocytes. This observation suggests that the T-cell-mediated surveillance of the integrity of the genome may extend to some intronic regions.
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页码:7976 / 7980
页数:5
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