INCREASED GLUTATHIONE IN CHRONIC LYMPHOCYTIC-LEUKEMIA LYMPHOCYTES

被引：35
作者：
FERRARIS, AM
ROLFO, M
MANGERINI, R
GAETANI, GF
机构：
[1] UNIV GENOA, IST NAZL RIC CANC, DIV HEMATOL ONCOL, GENOA, ITALY
[2] UNIV GENOA, IST ONCOL CLIN & SPERIMENTALE, GENOA, ITALY
来源：
AMERICAN JOURNAL OF HEMATOLOGY | 1994年 / 47卷 / 03期
关键词：
GLUTATHIONE; LEUKEMIA; LYMPHOCYTES;
D O I：
10.1002/ajh.2830470318
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Following reports on a variety of interactions between glutathione (GSH) concentration and clinical parameters in solid tumors, a study was undertaken in order to determine the GSH intracellular content of chronic lymphocytic leukemia (CLL) lymphocytes. The results from a group of 16 patients consecutively studied indicate that B-CLL cells have twice as much GSH as lymphocytes from normal subjects, suggesting that this measurement may be helpful in the understanding of the metabolic mechanism of the disease and the rationale of therapy. (C) 1994 Wiley-Liss, Inc.
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页码：237 / 238
页数：2
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