DYNAMIC BEHAVIOR OF HEPATITIS-C VIRUS QUASI-SPECIES IN PATIENTS UNDERGOING ORTHOTOPIC LIVER-TRANSPLANTATION

被引：93

作者：

MARTELL, M ^{[1
]}

ESTEBAN, JI ^{[1
]}

QUER, J ^{[1
]}

VARGAS, V ^{[1
]}

ESTEBAN, R ^{[1
]}

GUARDIA, J ^{[1
]}

GOMEZ, J ^{[1
]}

机构：

[1] UNIV VALL HEBRON,GEN HOSP,DEPT MED,LIVER UNIT,E-08035 BARCELONA,SPAIN

来源：

JOURNAL OF VIROLOGY | 1994年 / 68卷 / 05期

关键词：

D O I：

10.1128/JVI.68.5.3425-3436.1994

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have studied the distribution of viral sequences from the 5' noncoding region and from a fragment of the E2/NS2 region of the hepatitis C virus (HCV) genome in samples obtained before and after liver transplantation in two patients with HCV cirrhosis. The population of viral sequences in both regions were established by sequencing cloned PCR products. In both cases, the complexity of the viral quasispecies decreased after transplantation, although the consensus nucleotide and amino acid sequences remained unchanged. It is suggested that both positive and negative selection and random sampling events contribute substantially in shaping the genetic composition of HCV quasispecies and that recurrence of HCV infection may occur under equilibrium conditions.

引用

页码：3425 / 3436

页数：12