THE AFFINITY OF THE EXCISED BINDING DOMAIN OF FK-506 FOR THE IMMUNOPHILIN FKBP12

被引：15
作者：
TEAGUE, SJ
STOCKS, MJ
机构：
[1] Fisons Pharmaceuticals PLC, Loughborough, LE11 ORH, Bakewell Road
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 10期
关键词：
D O I：
10.1016/S0960-894X(01)80992-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The affinity of the binding domain of FK-506 was determined, in the absence of the constraints imposed upon it by the macrocyclic framework. Removal of those parts of FK-506 not involved in the binding of FK-506 to FKBP12 results in a 50-fold drop in affinity.
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页码：1947 / 1950
页数：4
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