THE ROLE OF CALCIUM IN RAT OLIGODENDROCYTE INJURY AND REPAIR

被引：32

作者：

SCOLDING, NJ ^{[1
]}

MORGAN, BP ^{[1
]}

CAMPBELL, AK ^{[1
]}

COMPSTON, DAS ^{[1
]}

机构：

[1] UNIV WALES COLL MED,DEPT MED BIOCHEM,CARDIFF CF4 4XN,S GLAM,WALES

来源：

NEUROSCIENCE LETTERS | 1992年 / 135卷 / 01期

基金：

英国惠康基金;

关键词：

OLIGODENDROCYTE; CALCIUM; CELL INJURY; COMPLEMENT; DEMYELINATING DISEASE;

D O I：

10.1016/0304-3940(92)90144-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The role of intracellular calcium in oligodendrocyte injury is investigated using cultured rat oligodendrocytes. Calcium ionophores A23187 and ionomycin mimic both complement and perforin attack, causing oligodendrocyte lysis at concentrations which do not lyse other glia. Membrane vesiculation, the mechanism by which oligodendrocytes resist and recover from complement and perforin attack, is also induced by A23187. Oligodendrocytes are more susceptible to complement attack in the presence of a calmodulin inhibitor (W7), which also inhibits vesiculation. These results imply that calmodulin is involved in membrane repair from complement attack. and indicate that changes in intracellular calcium play an important yet paradoxical role in the oligodendrocyte response to injury, dictating both susceptibility and cellular recovery.

引用

页码：95 / 98

页数：4

共 27 条

[1] CALCIUM-STIMULATED PROTEOLYSIS IN MYELIN - EVIDENCE FOR A CA-2+-ACTIVATED NEUTRAL PROTEINASE ASSOCIATED WITH PURIFIED MYELIN OF RAT CNS [J].

BANIK, NL ;

MCALHANEY, WW ;

HOGAN, EL .

JOURNAL OF NEUROCHEMISTRY, 1985, 45 (02) :581-588

[2] A SYRINGE MODIFICATION FOR THE SIMPLE AND RAPID DISSOCIATION OF POSTNATAL RAT CEREBRAL TISSUE FOR PREPARING PRIMARY CULTURES OF MIXED GLIAL-CELLS [J].

CHAPMAN, J ;

RUMSBY, MG .

NEUROSCIENCE LETTERS, 1982, 34 (03) :307-313

[3] GLUTAMATE NEUROTOXICITY AND DISEASES OF THE NERVOUS-SYSTEM [J].

CHOI, DW .

NEURON, 1988, 1 (08) :623-634

[4]

COMPSTON DAS, 1991, TRENDS NEUROSCI, V14, P175

[5] CA2+ RESPONSES TO INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR IN CULTURED HUMAN SKIN FIBROBLASTS - POSSIBLE IMPLICATIONS FOR REYE SYNDROME [J].

CORKEY, BE ;

GESCHWIND, JF ;

DEENEY, JT ;

HALE, DE ;

DOUGLAS, SD ;

KILPATRICK, L .

JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (03) :778-786

[6] THE ROLE OF CALCIUM IN CELL-DEATH [J].

FARBER, JL .

LIFE SCIENCES, 1981, 29 (13) :1289-1295

[7]

HIDAKA H, 1985, CALMODULIN ANTAGONIS, P13

[8]

KIZAKI H, 1989, J IMMUNOL, V143, P1790

[9] INTRACELLULAR CA-2+ AND CELL INJURY - A PARADOXICAL ROLE OF CA-2+ IN COMPLEMENT MEMBRANE ATTACK [J].

MORGAN, BP ;

LUZIO, JP ;

CAMPBELL, AK .

CELL CALCIUM, 1986, 7 (5-6) :399-411

[10]

MORGAN BP, 1989, BIOCHEM J, V264, P1

← 1 2 3 →