EFFECT OF BIGUANIDE DERIVATIVES ON LIPID-METABOLISM AND BLOOD MONONUCLEAR FUNCTION IN PATIENTS WITH INSULIN-DEPENDENT DIABETES-MELLITUS

The paper provides the biochemical and immunological findings from 287 patients with Type I diabetes mellitus with regard to the pattern of their management. It has been shown that the patients treated with non-physiological large-dose insulin more frequently display clinical signs of atherosclerosis profound changes in the serum lipid profile and some immunological parameters. It is concluded that chronic insulin overdosage may play a role in the mechanisms of atherosclerosis development. It is indicated that the use of biguanidine derivatives in the treatment of patients with Type I diabetes mellitus concurrent with insulin overdosage leads to correction of most unfavorable changes in biochemical and immunological parameters.