REVERSAL OF DIASTEREOFACIAL SELECTIVITY IN THE ADDITION-REACTION OF ORGANOMETALLICS TO CHIRAL IMINES

被引：62

作者：

UKAJI, Y

WATAI, T

SUMI, T

FUJISAWA, T

机构：

来源：

CHEMISTRY LETTERS | 1991年 / 09期

关键词：

D O I：

10.1246/cl.1991.1555

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

It was observed that diastereofacial selectivity in the addition reaction of organometallics to the chiral imines derived from (R)-2-methoxy-1-phenylethylamine was regulated under appropriate conditions; i.e., organolithium and organocerium reagents added from the re-face of the chiral imines selectively, while organocopper reagents attacked from the si-face. The utility of the present method was demonstrated in the enantioselective synthesis of solenopsin A.

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页码：1555 / 1558

页数：4

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