ADAPTIVE RESPONSE IN IRRADIATED HUMAN-LYMPHOCYTES - RADIOBIOLOGICAL AND GENETIC-ASPECTS

被引：26
作者：
KHANDOGINA, EK
MUTOVIN, GR
ZVEREVA, SV
ANTIPOV, AV
ZVEREV, DO
AKIFYEV, AP
机构：
[1] NI PIROGOV MED INST,MOSCOW,USSR
[2] ACAD SCI USSR,INST CHEM PHYS,MOSCOW 117977,USSR
来源：
MUTATION RESEARCH | 1991年 / 251卷 / 02期
关键词：
ADAPTIVE RESPONSE; CHROMOSOME ABERRATIONS; HUMAN LYMPHOCYTES;
D O I：
10.1016/0027-5107(91)90073-W
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The adaptive response (AR) in human lymphocytes in different experimental protocols was investigated. The AR was found to be present in cells pre-exposed to 3 cGy of X-rays in G0, G1 and S phase as well as with tritiated water (4-mu-Ci/ml) when the 'challenge' dose was given in G2. There was no AR after prior exposure of the cells in S phase to secondary irradiation from 70 GeV protons. The AR was not observed after preliminary X-irradiation of the lymphocytes in G0 and G1 and 'challenge' irradiation in G1. Cells from 6 patients with Down's syndrome were tested. At least 5 of them did not show the AR. The AR is considered to be a phenomenon of the antimutagenic aftereffect.
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页码：181 / 186
页数：6
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