REGULATION OF THE CYTOKINE PRODUCTION OF ALLERGEN-SPECIFIC HUMAN T-CELL CLONES BY THE ALLERGEN

被引：10

作者：

CARBALLIDO, JM ^{[1
]}

CARBALLIDOPERRIG, N ^{[1
]}

HEUSSER, C ^{[1
]}

BLASER, K ^{[1
]}

机构：

[1] CIBA GEIGY AG, PHARMACEUT RES, CH-4002 BASEL, SWITZERLAND

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1992年 / 99卷 / 2-4期

关键词：

BEE VENOM; HLA; IFN-GAMMA; IL-4; PHOSPHOLIPASE-A2; TH SUBSETS;

D O I：

10.1159/000236286

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Human T-cell clones to bee venom phospholipase A2 (PLA), isolated from allergic, hyposensitized and hyperimmune individuals to bee sting, secrete both IL-4 and IFN-gamma after antigen stimulation. However, the production of IL-4 was higher than the production of IFN-gamma. The threshold of the antigen dose required for IL-4 secretion was lower than for IFN-gamma. Furthermore, clones derived from allergic and hyposensitized individuals generally expressed increasing ratios of IL-4/IFN-gamma production with increasing concentrations of PLA. In contrast, most clones isolated from hyperimmune subjects expressed an opposite dose relationship for IL-4/IFN-gamma production.

引用

页码：366 / 369

页数：4

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