INHIBITORS OF POLYAMINE BIOSYNTHESIS AFFECT THE EXPRESSION OF GENES ENCODING CYTOSKELETAL PROTEINS

被引：38

作者：

KAMINSKA, B ^{[1
]}

KACZMAREK, L ^{[1
]}

GRZELAKOWSKASZTABERT, B ^{[1
]}

机构：

[1] M NENCKI INST EXPTL BIOL,TISSUE CULTURE FACIL,PL-02093 WARSAW,POLAND

来源：

FEBS LETTERS | 1992年 / 304卷 / 2-3期

关键词：

POLYAMINE; DFMO; MGBG; MOUSE SPLENOCYTE; BETA-ACTIN; ALPHA-TUBULIN MESSENGER RNA; CYTOSKELETON;

D O I：

10.1016/0014-5793(92)80618-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The polyamines are ubiquitous components of mammalian cells. Those compounds have been postulated to play an important role in different cellular functions including the reorganization of cytoskeleton associated with the cell cycle. In the studies reported here, it was found that inhibitors of polyamine biosynthesis, methylglyoxal-bis[quanylhydrazone] (MGBG) and difluoromethylornithine (DFMO), prevent mitogen-induced accumulation of mRNAs encoding major cytoskeletal components, beta-actin and alpha-tubulin, in mouse splenocytes. These findings suggest mechanisms through which polyamines may exert their effects on the cytoskeleton integrity.

引用

页码：198 / 200

页数：3

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