ELEVATED LIPOPROTEIN(A) LEVELS IN RENAL-TRANSPLANTATION AND HEMODIALYSIS-PATIENTS

被引：46

作者：

HEIMANN, P

JOSEPHSON, MA

FELLNER, SK

THISTLETHWAITE, JR

STUART, FP

DASGUPTA, A

机构：

[1] UNIV CHICAGO,PRITZKER SCH MED,DEPT PATHOL,CHICAGO,IL 60637

[2] UNIV CHICAGO,PRITZKER SCH MED,DEPT MED,CHICAGO,IL 60637

[3] UNIV CHICAGO,PRITZKER SCH MED,DEPT SURG,CHICAGO,IL 60637

来源：

AMERICAN JOURNAL OF NEPHROLOGY | 1991年 / 11卷 / 06期

关键词：

LIPOPROTEIN(A); HYPERLIPIDEMIA; ATHEROSCLEROSIS; RENAL TRANSPLANTATION; HEMODIALYSIS;

D O I：

10.1159/000168361

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Hyperlipidemia poses a risk for cardiovascular disease in both hemodialysis and renal transplantation patients. Although lipid profiles differ between the 2 populations, we evaluated the possibility that both groups have similar abnormalities of lipoprotein(a) [Lp(a)]. Mean serum Lp(a) and standard error of the mean (SEM) in hemodialysis and transplant recipients was 16.6 +/- 4.7 and 18.3 +/- 3.6 mg/dl, respectively, compared with 10.7 +/- 4.1 mg/dl in healthy controls, p < 0.05. That serum Lp(a) levels are significantly elevated in dialysis and renal transplantation patients suggests at least 1 common pathogenic mechanism for the high incidence of atherosclerosis in both groups.

引用

页码：470 / 474

页数：5

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