Phytochemical Analysis and Antidepressant Activity of Ixora coccinea Extracts in Experimental Models of Depression in Mice

被引：8

作者：

Surana, Ajaykumar Rikhabchand ^{[1
]}

Wagh, Rajendra Dayaram ^{[2
]}

机构：

[1] SMBT Coll Pharm, Dhamangaon, India

[2] ARA Coll Pharm, Dhule, India

来源：

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES | 2018年 / 15卷 / 02期

关键词：

Antidepressant activity; forced swim test; GC-MS; Ixora coccinea; open field test; tail suspension test;

D O I：

10.4274/tjps.14622

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Objectives: The present study aims to assess the antidepressant activity of Ixora coccinea extracts in mice and phytochemical analysis of the active extract by GC-MS. Materials and Methods: After oral administration of extracts, tail suspension test (TST), force swim tests (FST), and open field tests (OFT) were performed to assess the antidepressant activity. GC-MS analysis of methanol extract of I. coccinea was performed to ascertain the chemical constituents in the bioactive extract. Results: The methanol extract of I. coccinea at dose of 100 and 200 mg/kg body weight, p.o. significantly reduced the total duration of immobility in the TST as well as FST (p<0.01). I. coccinea extracts showed no significant changes in locomotor activity in OFT. Conclusion: The methanol extract of I. coccinea possesses antidepressant-like properties in mice with no significant effect on locomotor activity in OFT.

引用

页码：130 / 135

页数：6

共 37 条

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