Decline in adverse outcomes and death in tuberculosis patients in Malawi: association with HIV interventions

被引：4

作者：

Kanyerere, H. ^{[1
]}

Mganga, A. ^{[2
]}

Harries, A. D. ^{[3
,4
]}

Tayler-Smith, K. ^{[5
]}

Zachariah, R. ^{[5
]}

Jahn, A. ^{[2
,6
]}

Chimbwandira, F. M. ^{[2
]}

Mpunga, J. ^{[1
]}

机构：

[1] Natl TB Control Programme, Community Hlth Sci Unit, Lilongwe, Malawi

[2] Minist Hlth, Dept HIV & AIDS, Lilongwe, Malawi

[3] Int Union TB & Lung Dis, Paris, France

[4] London Sch Hyg & Trop Med, London WC1, England

[5] Operat Ctr Brussels, Med Sans Frontieres, Dept Med, Msf Luxembourg, Belgium

[6] Univ Washington, Int Training & Educ Ctr Hlth Malawi, Seattle, WA 98195 USA

来源：

PUBLIC HEALTH ACTION | 2015年 / 5卷 / 02期

关键词：

tuberculosis outcomes; death; Malawi; HIV/AIDS; antiretroviral therapy;

D O I：

10.5588/pha.14.0109

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Between 2000 and 2012, the annual numbers of patients treated for tuberculosis (TB) in Malawi declined by 28%, from 28 234 to 20 463. During this time, the proportion of TB patients tested for the human immunodeficiency virus (HIV) increased from 6% to 87%. Most HIV-infected patients received cotrimoxazole preventive therapy, and the proportion receiving antiretroviral therapy increased to 88%. Between 2000 and 2008 there was a significant decline in all adverse outcomes (from 31% to 14%), and particularly in deaths (from 23% to 10%) and loss to follow-up (from 5.2% to 1.9%, P < 0.001). After 2008, there was no decrease in any adverse outcome. Ways to further reduce TB-associated mortality are discussed.

引用

页码：116 / 118

页数：3

共 11 条

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