Role of Adipokines and Cytokines in Non-alcoholic Fatty Liver Disease

被引:79
作者
Abenavoli, Ludovico [1 ]
Peta, Valentina [1 ]
机构
[1] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Viale Europa, I-88100 Catanzaro, Italy
关键词
Adipokines; cytokines; fibrosis; non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; steatosis;
D O I
10.2174/1574887109666141216102458
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
One of the most common hepatic manifestations of the metabolic syndrome is non-alcoholic fatty liver disease (NAFLD). This disease varies from simple steatosis to cirrhosis and hepatocellular carcinoma. Different molecules secreted from adipose tissue such as adiponectin, leptin, resistin and visfatin and pro-inflammatory cytokines such as tumour necrosis factor-alpha, and interleukins, can be involved in the pathogenesis of NAFLD. In this review we describe the role of these adipokines and cytokines in the pathogenesis of NAFLD. We comment on their potential use as non-invasive biomarkers of steatosis and fibrosis, and their potential therapeutic role.
引用
收藏
页码:134 / 140
页数:7
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