A SHORT AND EFFICIENT SYNTHESIS OF ECHIGUANINE-A AND ECHIGUANINE-B - POTENT INHIBITORS OF PHOSPHATIDYLINOSITOL-4-KINASE

被引：12
作者：
SHIH, C
HU, Y
机构：
[1] Lilly Research Laboratories, Eli Lilly and Company, Indianapolis
来源：
TETRAHEDRON LETTERS | 1994年 / 35卷 / 27期
关键词：
D O I：
10.1016/S0040-4039(00)76939-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient synthesis which utilizes a palladium catalyzed carbonylation reaction between 2-pivaloyl-7-iodo-7-deazaguanine and 3-aminopropionitrile as a key step was developed for the preparation of a new class of pyrrolopyrimidine based PI 4-Kinase inhibitors: Echiguanines A and B.
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收藏
页码：4677 / 4680
页数：4
相关论文
共 10 条
  • [1] AKIMOTO H, 1991, Proceedings of the American Association for Cancer Research Annual Meeting, V32, P327
  • [2] NOVEL PYRROLO[2,3-D]PYRIMIDINE ANTIFOLATES - SYNTHESIS AND ANTITUMOR ACTIVITIES
    MIWA, T
    HITAKA, T
    AKIMOTO, H
    NOMURA, H
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (02) : 555 - 560
  • [3] ISOLATION AND STRUCTURE DETERMINATION OF NOVEL PHOSPHATIDYLINOSITOL KINASE INHIBITORS, ECHIGUANINE-A AND ECHIGUANINES-B, FROM STREPTOMYCES-SP
    NISHIOKA, H
    SAWA, T
    NAKAMURA, H
    IINUMA, H
    IKEDA, D
    SAWA, R
    NAGANAWA, H
    HAYASHI, C
    HAMADA, M
    TAKEUCHI, T
    IITAKA, Y
    UMEZAWA, K
    [J]. JOURNAL OF NATURAL PRODUCTS, 1991, 54 (05): : 1321 - 1325
  • [4] NISHIOKA H, Patent No. 4217681
  • [5] THE SYNTHESIS OF N-(2-AMINO-4-SUBSTITUTED [(PYRROLO[2,3-D]-PYRIMIDIN-5-YL)ETHYL]BENZOYL)-L-GLUTAMIC ACIDS AS ANTINEOPLASTIC AGENTS
    SHIH, C
    GOSSETT, LS
    [J]. HETEROCYCLES, 1993, 35 (02) : 825 - 841
  • [6] Stothers J. B., 1972, CARBON 13 NMR SPECTR, P153
  • [7] Suhadolnik R. J., 1979, NUCLEOSIDES BIOL PRO, P158
  • [8] SUHADOLNIK RJ, 1970, NUCLEOSIDE ANTIBIOTI, P315
  • [9] A DIDEAZATETRAHYDROFOLATE ANALOG LACKING A CHIRAL CENTER AT C-6, N-[4-[2-(2-AMINO-3,4-DIHYDRO-4-OXO-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)ETHYL]BENZOYL]-L-GLUTAMIC ACID, IS AN INHIBITOR OF THYMIDYLATE SYNTHASE
    TAYLOR, EC
    KUHNT, D
    SHIH, C
    RINZEL, SM
    GRINDEY, GB
    BARREDO, J
    JANNATIPOUR, M
    MORAN, RG
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (23) : 4450 - 4454
  • [10] VLAHOS C, UNPUB
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