MECHANISM OF MODULATION OF GABA-ACTIVATED CURRENT BY INTERNAL CALCIUM IN RAT CENTRAL NEURONS

被引：29
作者：
MARCHENKO, SM
机构：
[1] A.A. Bogomoletz Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev
来源：
BRAIN RESEARCH | 1991年 / 546卷 / 02期
关键词：
GAMMA-AMINOBUTYRIC ACID; PURKINJE CELL; CEREBELLUM; IONIC CONDUCTANCE; INTERNAL PERFUSION;
D O I：
10.1016/0006-8993(91)91502-R
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
GABA-activated currents in Purkinje cells isolated from rat cerebellum were investigated. Increased of intracellular Ca2+ in the physiological range of concentrations caused a decrease in GABA-activated chloride currents. This effect resulted from a decrease of both the maximal values of GABA-activated currents and possibly from the affinity of GABA(A) receptors. Therefore, the mechanism of Ca2+ effect on GABA(A) receptors in central rat neurons differs from that in bullfrog sensory neurons.
引用
收藏
页码：355 / 357
页数：3
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