POTENTIATING EFFECT OF CCK AND SECRETIN ON RAT EXOCRINE PANCREAS AND ITS CHOLINERGIC DEPENDENCE

被引：22

作者：

MORIYOSHI, Y ^{[1
]}

SHIRATORI, K ^{[1
]}

WATANABE, S ^{[1
]}

TAKEUCHI, T ^{[1
]}

机构：

[1] TOKYO WOMENS MED COLL,DEPT GASTROENTEROL,8-1 KAWADA CHO,SHINJUKU KU,TOKYO 162,JAPAN

来源：

PANCREAS | 1991年 / 6卷 / 05期

关键词：

CHOLECYSTOKININ; SECRETIN; ATROPINE; PANCREATIC SECRETION; POTENTIATION;

D O I：

10.1097/00006676-199109000-00015

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

We investigated whether physiological doses of cholecystokinin (CCK) potentiate the stimulating effect of a physiological dose of secretin on exocrine pancreatic secretion, and the effect of atropine on this potentiating action in rats. Pure pancreatic juice was collected from anesthetized rats prepared by pancreatic duct and bile duct cannulation. Intravenous infusion of CCK-8 in three different doses, 0.03, 0.06, and 0.12-mu-g/kg/h, significantly increased pancreatic juice volume and amylase output, dose-dependently. Simultaneous infusion of CCK-8 in graded doses with secretin in a dose of 0.03 CU/kg/h, produced a dose-related increase in pancreatic secretory response significantly greater than the response to CCK-8 alone (p < 0.05) and greater than the sum of the response to secretin alone and CCK-8 alone. The incremental pancreatic secretion, including juice volume and amylase output, in response to intravenous infusion of CCK-8 with secretin, was significantly suppressed by intravenous administration of atropine in a dose of 100-mu-g/kg/h (p < 0.01). Thus, it is concluded that CCK-8 and secretin in physiological doses potentiate each other's stimulatory action on exocrine pancreatic secretion and this potentiating action appears to be cholinergic-dependent.

引用

页码：603 / 608

页数：6

共 24 条

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