ABSOLUTE-CONFIGURATION OF CURACIN-A, A NOVEL ANTIMITOTIC AGENT FROM THE TROPICAL MARINE CYANOBACTERIUM LYNGBYA-MAJUSCULA

被引：53

作者：

NAGLE, DG

GERALDS, RS

YOO, HD

GERWICK, WH

KIM, TS

NAMBU, M

WHITE, JD

机构：

[1] OREGON STATE UNIV,COLL PHARM,CORVALLIS,OR 97331

[2] OREGON STATE UNIV,DEPT CHEM,CORVALLIS,OR 97331

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 08期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/0040-4039(95)00030-G

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Curacin A is a structurally novel antimitotic agent isolated from the Caribbean cyanobacterium Lyngbya majuscula. Its planar structure has been previously determined from a spectroscopic investigation. Here, we define the complete relative and absolute configuration of curacin A by comparison of products obtained from chemical degradation of the natural product with the same substances prepared by synthesis. Curacin A is shown to have 2R, 13R, 19R, 21S absolute configuration.

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页码：1189 / 1192

页数：4

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