REPEAT LENGTH VARIATION IN THE DOPAMINE D4 RECEPTOR GENE SHOWS NO EVIDENCE OF ASSOCIATION WITH SCHIZOPHRENIA

被引：37
作者：
DANIELS, J
WILLIAMS, J
MANT, R
ASHERSON, P
MCGUFFIN, P
OWEN, MJ
机构：
[1] UNIV WALES COLL MED,DEPT MED PSYCHOL,CARDIFF CF4 4XN,S GLAM,WALES
[2] UNIV WALES COLL MED,DEPT MED GENET,CARDIFF CF4 4XN,WALES
来源：
AMERICAN JOURNAL OF MEDICAL GENETICS | 1994年 / 54卷 / 03期
关键词：
ALLELIC FORMS; CYTOPLASMIC LOOP; SCHIZOPHRENIA;
D O I：
10.1002/ajmg.1320540313
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The D4 receptor has been shown to exist in several allelic forms (Van Tol et al., Nature 358:149-152, 1992) reflecting variation in the number of 48 base-pair sequence repeats in the putative cytoplasmic loop. We report a comparison of repeat length variation between schizophrenic patients and controls. Our sample of 106 unrelated schizophrenic cases and 119 controls showed no significant differences in allele or genotype distribution between patients and controls. In particular, we were unable to support the previous observation of an excess of 4-repeat homozygotes in patients. (C) 1994 Wiley-Liss, Inc.
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收藏
页码：256 / 258
页数：3
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