HUMAN CORTICOTROPIN-RELEASING HORMONE TEST IN PATIENTS WITH HYPOTHALAMO-PITUITARY-ADRENOCORTICAL DISORDERS

被引：11

作者：

FUKATA, J

SHIMIZU, N

IMURA, H

HIBI, I

TANAKA, K

TANAKA, T

NAKAGAWA, S

TAKEBE, K

KIMURA, K

YOSHINAGA, K

TAKAKURA, K

DEMURA, H

IRIE, M

MIYACHI, Y

YANAIHARA, N

YOSHIMI, T

MIURA, K

KUWAYAMA, A

OTA, Z

KATO, Y

SAITO, S

TAKAHARA, J

HASHIMOTO, K

NAWATA, H

MATSUKURA, S

机构：

[1] KYOTO UNIV, FAC MED, DEPT MED, DIV 2, KYOTO, KYOTO 606, JAPAN

[2] TEIKYO UNIV, SCH MED, DEPT MED 3, TOKYO, TOKYO 173, JAPAN

[3] NATL CHILDRENS HOSP, DEPT ENDOCRINOL & METAB, ENDOCRINE RES LAB, TOKYO, TOKYO 154, JAPAN

[4] HOKKAIDO UNIV, SCH MED, DEPT MED 2, SAPPORO, HOKKAIDO 060, JAPAN

[5] HIROSAKI UNIV, SCH MED, DEPT MED 3, HIROSAKI, AOMORI 036, JAPAN

[6] AOMORI PREFECTURAL CENT HOSP, DEPT ENDOCRINOL, AOMORI, AOMORI 030, JAPAN

[7] TOHOKU UNIV, SCH MED, DEPT INTERNAL MED 2, SENDAI, MIYAGI 980, JAPAN

[8] UNIV TOKYO, DEPT NEUROSURG, TOKYO 113, JAPAN

[9] TOKYO WOMENS MED COLL, INST CLIN ENDOCRINOL, DEPT MED, TOKYO 162, JAPAN

[10] TOHO UNIV, SCH MED, DEPT INTERNAL MED 1, TOKYO, TOKYO 143, JAPAN

[11] UNIV SHIZUOKA, DEPT PHARMACEUT SCI, SHIZUOKA, SHIZUOKA 422, JAPAN

[12] HAMAMATSU UNIV SCH MED, DEPT INTERNAL MED 2, HAMAMATSU, SHIZUOKA 43131, JAPAN

[13] GIFU UNIV, SCH MED, DEPT INTERNAL MED 3, GIFU 500, JAPAN

[14] NAGOYA NATL HOSP, DEPT NEUROSURG 1, NAGOYA, AICHI 460, JAPAN

[15] OKAYAMA UNIV, SCH MED, DEPT INTERNAL MED 3, OKAYAMA 700, JAPAN

[16] SHIMANE MED UNIV, DEPT MED, DIV 1, IZUMO, SHIMANE 693, JAPAN

[17] UNIV TOKUSHIMA, SCH MED, DEPT INTERNAL MED 1, TOKUSHIMA 770, JAPAN

[18] KAGAWA MED SCH, DEPT INTERNAL MED 1, MIKI, KAGAWA 76107, JAPAN

[19] KOCHI MED SCH, DEPT INTERNAL MED 2, KOCHI, KOCHI 783, JAPAN

[20] KYUSHU UNIV, FAC MED, DEPT INTERNAL MED 3, FUKUOKA 812, JAPAN

[21] MIYAZAKI MED COLL, DEPT INTERNAL MED 3, MIYAZAKI, MIYAZAKI 88916, JAPAN

来源：

ENDOCRINE JOURNAL | 1993年 / 40卷 / 05期

关键词：

HUMAN CORTICOTROPIN-RELEASING HORMONE; HYPOTHALAMO-PITUITARY-ADRENAL DISORDERS; DIAGNOSTIC DRUG; GLUCOCORTICOID;

D O I：

10.1507/endocrj.40.597

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To assess the diagnostic usefulness of a synthetic human corticotropin-releasing hormone (CRH) formulation (Code No. MCI-028), we administered 100 mu g of the peptide intravenously to 183 patients with hypothalamo-pituitary-adrenocortical (HPA) disorders, and obtained the following findings. Among the 183 patients, data from 125 patients were suitable for analyzing the effects of the test. In patients with Cushing's disease, high plasma adrenocorticotropic hormone (ACTH) and cortisol levels increased further in response to MCI-028, while in patients with adrenal Cushing's syndrome, low ACTH and high cortisol values remained unchanged. In patients with pituitary-type hypopituitarism or isolated ACTH deficiency, low ACTH and cortisol levels responded poorly or insignificantly to MCI-028, whereas those with hypothalamic hypopituitarism showed delayed and considerable degree of responses of plasma ACTH and little increase in plasma cortisol levels. In Addison's disease, high plasma ACTH increased further in response to MCI-028, but low cortisol levels did not change. In patients with Cushing's syndrome soon after successful surgical treatment, plasma ACTH responsiveness was low or different depending on the clinical course of the patient. Patients treated with high doses of glucocorticoids for non-endocrine diseases tended to show impaired ACTH and cortisol responsiveness to MCI-028. Side effects, including the transient flushing which was observed most frequently in this study, did not cause any clinical problems.

引用

页码：597 / 606

页数：10

共 27 条

[1] THE CORTICOTROPIN-RELEASING FACTOR STIMULATION TEST - AN AID IN THE EVALUATION OF PATIENTS WITH CUSHINGS-SYNDROME [J].