ACTINOMYCINS AS PROTEINASE-INHIBITORS

被引：10

作者：

BETZEL, C

RACHEV, R

DOLASHKA, P

GENOV, N

机构：

[1] BULGARIAN ACAD SCI,INST ORGAN CHEM,BU-1040 SOFIA,BULGARIA

[2] EUROPEAN MOLEC BIOL LAB,HAMBURG,GERMANY

[3] BULGARIAN ACAD SCI,INST MICROBIOL,BU-1113 SOFIA,BULGARIA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1993年 / 1161卷 / 01期

关键词：

ACTINOMYCIN-D; ACTINOMYCIN-SG3; BACITRACIN-A; GRAMICIDIN-S; PROTEINASE INHIBITOR; SUBTILISIN;

D O I：

10.1016/0167-4838(93)90194-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel actinomycin (Act SG3) from a strain of Streptomyces galbus var. C-72, as well as actinomycin D (Act D) were found to act as competitive inhibitors of serine proteinases from microorganisms. The inhibitory properties of Act SG3 and Act D are compared with these of other peptide antibiotics, namely bacitracin A (Bac A) and gramicidin S (Gr S). The last compound has only a weak inhibitory effect. The following order of affinity for the four peptide antibiotics towards subtilisin DY and proteinase K was observed: Bac A > Act D > Act SG3 = Gr S. The affinity towards thermitase changes as follows: Act SG3 = Act D > Bac A > Gr S.

引用

页码：47 / 51

页数：5

共 21 条

[1]

BAUDYS M, 1982, INT J PEPT PROT RES, V19, P32

[2]

BETZEL C, 1990, STRUCT METHODS, V2, P129

[3] INHIBITION BY BACITRACIN OF HIGH-AFFINITY BINDING OF I-125-LABELED ALPHA-2-M TO PLASMA-MEMBRANES [J].