GENETICAL CONTROL OF CONCENTRATION OF ME7 SCRAPIE AGENT IN BRAIN OF MICE

Genetical variation in the incubation period of the ME7 scrapie agent in mice is controlled by the gene, sinc. The strain with the p7 alleles for long incubation period does not differ in the titre of scrapie in the spleen from strains carrying the short incubation period s7 alleles, for the period subsequent to 60 days after intracerebral injection. The difference between the alleles is shown in the titre of the agent in the brain where there is a long initial delay in the increase of the titre with the p7 alleles although the subsequent rate of increase and terminal titre are similar for both alleles. © 1968.