ANCA ANTIIDIOTYPE ANTIBODIES AND THE TREATMENT OF SYSTEMIC VASCULITIS WITH INTRAVENOUS IMMUNOGLOBULIN

被引：109

作者：

JAYNE, DRW ^{[1
]}

ESNAULT, VLM ^{[1
]}

LOCKWOOD, CM ^{[1
]}

机构：

[1] CHU NANTES,IMMUNOL CLIN,SERV NEPHROL,F-44035 NANTES,FRANCE

来源：

JOURNAL OF AUTOIMMUNITY | 1993年 / 6卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1006/jaut.1993.1018

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The presence of anti-idiotype antibodies (anti-id) to anti-neutrophil cytoplasma autoantibodies (ANCA) in intravenous immunoglobulin (IVIg) and remission sera from patients with systemic vasculitis, and the use of IVIg as an alternative therapeutic agent in open studies, has suggested a role for idiotypic regulation in the normal control of these disorders. Clinical benefit with IVIg has been reported in 15/16 patients, with sustained remission in eight. The ability of IVIg to produce lasting remission has been associated with a fall in ANCA levels and stimulation of endogenous immunoglobulin production. IVIg has the potential to influence the pathogenetic process in patients with vasculitis at several stages, and an influence on the idiotypic regulation of ANCA may explain the observed clinical responses and point to possible targets for more specific immunotherapy in the future. © 1993 Academic Press Limited.

引用

页码：207 / 219

页数：13

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