ASSIGNMENT OF A HUMAN SERUM GLYCOPROTEIN-SP-40,40 GENE (CLI) TO CHROMOSOME-8

被引：22

作者：

TOBE, T ^{[1
]}

MINOSHIMA, S ^{[1
]}

YAMASE, S ^{[1
]}

CHOI, NH ^{[1
]}

TOMITA, M ^{[1
]}

SHIMIZU, N ^{[1
]}

机构：

[1] KEIO UNIV,SCH MED,DEPT MOLEC BIOL,TOKYO 108,JAPAN

来源：

CYTOGENETICS AND CELL GENETICS | 1991年 / 57卷 / 04期

关键词：

D O I：

10.1159/000133144

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

SP-40,40 is a serum glycoprotein consisting of two different subunits (alpha and beta) assembled into a dimer by disulfide bonds. Northern blot hybridization, using total RNA from several cell lines, showed that SP-40,40 is expressed in glioblastoma and testicular tumor cells, as well as hepatoma cells. Spot blot hybridization of flow-sorted human chromosomes, using a SP-40,40 cDNA fragment as a probe, localized the gene for SP-40,40 to human chromosome 8. This gene has been given the designation CLI, for complement lysis inhibitor, by the Human Gene Nomenclature Committee.

引用

页码：193 / 195

页数：3

共 17 条

[1]

CHOI NH, 1989, MOL IMMUNOL, V26, P835

[2] CD59, AN LY-6-LIKE PROTEIN EXPRESSED IN HUMAN LYMPHOID-CELLS, REGULATES THE ACTION OF THE COMPLEMENT MEMBRANE ATTACK COMPLEX ON HOMOLOGOUS CELLS [J].