ON THE POSSIBLE EFFECTS OF HOMEOSTATIC SHIFTS IN HUMAN EMBRYONIC-DEVELOPMENT

被引：1
|
作者：
CHELAFLORES, J
ACUNA, CE
机构：
[1] UNIV SIMON BOLIVAR,DEPT FIS,CARACAS,VENEZUELA
[2] CENT UNIV VENEZUELA,HOSP UNIV CARACAS,CARACAS,VENEZUELA
来源：
ACTA BIOTHEORETICA | 1990年 / 38卷 / 02期
关键词：
Congenital; Development; Genetic expression; Hyperthermia; malformations; Repressor hypothesis; Trisomies;
D O I：
10.1007/BF00047550
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Possible etiological factors of congenital malformations as well as of human trisomies are considered in the framework of the repressor hypothesis. In this approach gene expression is envisaged from the point of view of the functional variations of the total activation energy for normal gene expression in homeostatic equilibrium. We restrict our attention to variations of the total activation energy under the effect of temperature gradients. We discuss the evidence that hyperthermia may be an etiological factor for trisomies in humans. © 1990 Kluwer Academic Publishers.
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页码：135 / 142
页数：8
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