Serum Cobalamin and Dyslipidemia in Type 2 Diabetics

被引：0

作者：

Khoharo, Haji Khan ^{[1
]}

Memon, Iqbal Ahmed ^{[2
]}

Kazi, Shuja Anver ^{[3
]}

Qureshi, Fatima ^{[4
]}

机构：

[1] Isra Univ Hyderabad, Dept Med, Sindh, Pakistan

[2] Liaquat Univ Hosp Jamshoro, Dept Med, Sindh, Pakistan

[3] Isra Univ Hyderabad, Dept Physiol, Sindh, Pakistan

[4] Isra Univ Hyderabad, Dept Biochem, Sindh, Pakistan

来源：

JOURNAL OF THE LIAQUAT UNIVERSITY OF MEDICAL AND HEALTH SCIENCES | 2015年 / 14卷 / 01期

关键词：

Cobalamin; Dyslipidemia; Diabetes mellitus; Sindh;

D O I：

暂无

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

OBJECTIVE: To evaluate serum cobalamin with special reference to dyslipidemia in type 2 Diabetic subjects. STUDY DESIGN: Observational study PLACE AND DURATION: Department of Medicine, Isra University Hospital and Consultant Clinics Hyderabad, Sindh from January 2014 to July 2014. METHODOLOGY: A sample of 107 type 2 diabetic subjects was selected according to inclusion and exclusion criteria. Cobalamin was measured on Roche Cobas e411 chemistry analyzer and blood lipoproteins by standard laboratory methods. Data was analyzed by SPSS) version 21.0 using appropriate statistical test. P-value of <= 0.05 was considered significant. RESULTS: Cobalamin deficiency was noted in 51 (47.6%) of diabetics which has associated with dyslipidemia. Mean +/- SD of serum cobalamin in normal and reduced serum cobalamin groups were noted as 355 +/- 29.5 and 183 +/- 17.5 pg/ml respectively (p=0.0001). Triglycerides, total cholesterol, HDLc, LDLc and VLDLc differed significantly in the normal and reduced cobalamin subjects. Lipoprotein sub fractions showed a negative correlation with serum cobalamin. CONCLUSION: Cobalamin deficiency is common in type 2 diabetics associated with dyslipidemia.

引用

页码：21 / 25

页数：5

共 25 条

[1] Vitamin B12 deficiency is associated with adverse lipid profile in Europeans and Indians with type 2 diabetes [J].

Adaikalakoteswari, Antonysunil ;

Jayashri, Ramamurthy ;

Sukumar, Nithya ;

Venkataraman, Hema ;

Pradeepa, Rajendra ;

Gokulakrishnan, Kuppan ;

Anjana, Ranjit Mohan ;

McTernan, Philip G. ;

Tripathi, Gyanendra ;

Patel, Vinod ;

Kumar, Sudhesh ;

Mohan, Viswanathan ;

Saravanan, Ponnusamy .

CARDIOVASCULAR DIABETOLOGY, 2014, 13

[2] Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease - A randomized trial [J].

Albert, Christine M. ;

Cook, Nancy R. ;

Gaziano, J. Michael ;

Zaharris, Elaine ;

MacFadyen, Jean ;

Danielson, Eleanor ;

Buring, Julie E. ;

Manson, JoAnn E. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2008, 299 (17) :2027-2036

[3] Vitamin D supplementation in patients with diabetes mellitus type 2 on different therapeutic regimens: a one-year prospective study [J].

Alkharfy, Khalid M. ;

Al-Daghri, Nasser M. ;

Sabico, Shaun B. ;

Al-Othman, Abdulaziz ;

Moharram, Osama ;

Alokail, Majed S. ;

Al-Saleh, Yousef ;

Kumar, Sudhesh ;

Chrousos, George P. .

CARDIOVASCULAR DIABETOLOGY, 2013, 12

[4] Cardiovascular Risk Profiles amongst Women in a Multiethnic Population in Inner City Britain: A Potential Impact of Anaemia [J].

Chackathayil, Julia ;

Patel, Jeetesh V. ;

Gill, Paramjit S. ;

Potluri, Rahul ;

Natalwala, Ammar ;

Uppal, Hardeep ;

Lavu, Deepthi ;

Heun, Reinhard ;

Hughes, Elizabeth A. ;

Lip, Gregory Y. H. .

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2013, 2013

[5] Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) [J].

Cleeman, JI ;

Grundy, SM ;

Becker, D ;

Clark, LT ;

Cooper, RS ;

Denke, MA ;

Howard, WJ ;

Hunninghake, DB ;

Illingworth, DR ;

Luepker, RV ;

McBride, P ;

McKenney, JM ;

Pasternak, RC ;

Stone, NJ ;

Van Horn, L ;

Brewer, HB ;

Ernst, ND ;

Gordon, D ;

Levy, D ;

Rifkind, B ;

Rossouw, JE ;

Savage, P ;

Haffner, SM ;

Orloff, DG ;

Proschan, MA ;

Schwartz, JS ;

Sempos, CT ;

Shero, ST ;

Murray, EZ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (19) :2486-2497

[6] Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial [J].

de Jager, Jolien ;

Kooy, Adriaan ;

Lehert, Philippe ;

Wulffele, Michiel G. ;

van der Kolk, Jan ;

Bets, Daniel ;

Verburg, Joop ;

Donker, Ab J. M. ;

Stehouwer, Coen D. A. .

BMJ-BRITISH MEDICAL JOURNAL, 2010, 340 :1177

[7] Plasma homocysteine levels in patients with type 2 diabetes in a Mediterranean population: relation with nutritional and other factors [J].

Diakoumopoulou, E ;

Tentolouris, N ;

Kirlaki, E ;

Perrea, D ;

Kitsou, E ;

Psallas, M ;

Doulgerakis, D ;

Katsilambros, N .

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2005, 15 (02) :109-117

[8] Value of low-density lipoprotein particle number and size as predictors of coronary artery disease in apparently healthy men and women - The EPIC-Norfolk Prospective Population study [J].

El Harchaoui, Karim ;

van der Steeg, Wim A. ;

Stroes, Erik S. G. ;

Kuivenhoven, Jan Albert ;

Otvos, James D. ;

Wareham, Nicholas J. ;

Hutten, Barbara A. ;

Kastelein, John J. P. ;

Khaw, Kay-Tee ;

Boekholdt, S. Matthijs .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2007, 49 (05) :547-553

[9] Plasma homocysteine levels are associated with ulceration of the foot in patients with type 2 diabetes mellitus [J].

Gonzalez, R. ;

Pedro, T. ;

Real, Jose T. ;

Martinez-Hervas, S. ;

Abellan, M. R. ;

Lorente, R. ;

Priego, A. ;

Catala, M. ;

Chaves, F. J. ;

Ascaso, J. F. ;

Carmena, R. .

DIABETES-METABOLISM RESEARCH AND REVIEWS, 2010, 26 (02) :115-120

[10] Characterization and in vitro probiotic evaluation of lactic acid bacteria isolated from idli batter [J].

Iyer, Bharti K. ;

Singhal, Rekha S. ;

Ananthanarayan, Laxmi .

JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE, 2013, 50 (06) :1114-1121

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