Infections as a cause of autoimmune rheumatic diseases

被引：21

作者：

Sakkas, Lazaros I. ^{[1
]}

Bogdanos, Dimitrios P. ^{[1
]}

机构：

[1] Univ Thessaly, Sch Med, Biopolis, Dept Rheumatol & Clin Immunol, Larisa 40500, Greece

来源：

AUTOIMMUNITY HIGHLIGHTS | 2016年 / 7卷 / 01期

关键词：

Autoimmunity; Infection; Rheumatic disease; Rheumatoid arthritis; Systemic sclerosis;

D O I：

10.1007/s13317-016-0086-x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Exogenous and endogenous environmental exposures and particularly infections may participate in the breakage of tolerance and the induction of autoimmunity in rheumatic diseases. Response to infections apparently occurs years before clinical manifestations and features of autoimmunity, such as autoantibodies, are detected years before clinical manifestations in autoimmune rheumatic diseases. In this review, we summarize the current evidence for a potential causal link between infectious agents and rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, Sjogren's syndrome and ANCA-associated vasculitis.

引用

页数：8

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