EFFECTIVE IRON CHELATION FOLLOWING ORAL-ADMINISTRATION OF AN ISONIAZID-PYRIDOXAL HYDRAZONE

被引：94
作者：
HOY, T
HUMPHRYS, J
WILLIAMS, A
PONKA, P
JACOBS, A
机构：
[1] CHARLES UNIV, FAC MED, DEPT PATHOPHYSIOL, PRAGUE, CZECHOSLOVAKIA
[2] UNIV WALES WELSH NATL SCH MED, DEPT HAEMATOL, HEATH PK, CARDIFF CF4 4XW, S GLAMORGAN, WALES
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 1979年 / 43卷 / 03期
关键词：
D O I：
10.1111/j.1365-2141.1979.tb03771.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Summary. When isoniazid and pyridoxal are mixed in equimolar quantities a hydrazone is formed which is able to complex with iron. The oral administration of this compound to rats in single doses of 25–100 mg/kg leads to an increase in faecal iron excretion up to 8 times the normal level. In tissue culture the compound is able to remove iron from Chang cells. The results suggest that this compound may be of potential value for the oral therapy of iron overload. Copyright © 1979, Wiley Blackwell. All rights reserved
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页码：443 / 449
页数：7
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