DEMONSTRATION OF ADENYL CYCLASE ACTIVITY IN CANINE CARDIAC SARCOPLASMIC RETICULUM

被引:86
作者
ENTMAN, ML
LEVEY, GS
EPSTEIN, SE
机构
[1] the Cardiology Branch, National Heart Institute, National Institutes of Health, Bethesda, MD
关键词
D O I
10.1016/0006-291X(69)90466-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A microsomal fraction from canine cardiac muscle that actively accumulates calcium has been found to exhibit adenyl cyclase activity. The enzyme responds in a characteristic manner to fluoride and norepinephrine. Electron microscopic studies of the microsomal fraction demonstrate that it contains intact membrane vesicles; the lack of any glutamic dehydrogenase activity suggests that no contaminating mitochondrial fragments are present. In view of its active calcium accumulating ability, this fraction is believed to represent fragments of sarcoplasmic reticulum. This report represents the first demonstration of adenyl cyclase in cardiac sarcoplasmic reticulum. © 1969.
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