INTRAMOLECULAR COUPLING REACTION PROMOTED BY SMI2 IN A SYNTHETIC APPROACH OF FORSKOLIN

被引：0

作者：

ANIES, C

PANCRAZI, A

LALLEMAND, JY

PRANGE, T

机构：

[1] ECOLE POLYTECH,DCSO,SYNTH ORGAN LAB,F-91128 PALAISEAU,FRANCE

[2] UNIV PARIS NORD,CHIM STRUCT BIOMOLEC LAB,F-93012 BOBIGNY,FRANCE

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 42期

关键词：

RADICAL CYCLIZATIONS; BU(3)SNH; SMI2; PINACOLIC COUPLING REACTION; DESS-MARTIN OXIDATION; FORSKOLIN;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

From available hydroxy-aldehyde 6, propargylic derivative 8 was prepared and treated with Bu(3)SnH to give in 95% yield the bicyclic vinyl stannane 10. After 10 was converted into the diol 15, this latter was oxidized with the Dess-Martin reagent into the dialdehyde 4. Compound 4 was then submitted to a pinacolic coupling reaction leading to the bicyclic cis-diol 3 in a stereospecific manner.

引用

页码：7771 / 7774

页数：4