AZA-[2,3]-WITTIG REARRANGEMENTS OF VINYLAZIRIDINES AS A NOVEL ENTRY TO INDOLIZIDINE ALKALOIDS - ENANTIOSELECTIVE TOTAL SYNTHESIS OF INDOLIZIDINE 209D

被引：69

作者：

AHMAN, J ^{[1
]}

SOMFAI, P ^{[1
]}

机构：

[1] LUND UNIV,LUND INST TECHNOL,CTR CHEM,S-22100 LUND,SWEDEN

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 02期

关键词：

D O I：

10.1016/0040-4039(94)02236-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantioselective total synthesis of indolizidine 209D (1) from epoxy alcohol 4 is described. The key step in the sequence involves an aza-[2,3]-Wiltig rearrangement of vinylaziridine 7 to yield the cis-2,6-disubstituted tetrahydropyridine 8 in 98% yield and as a single detectable diastereomer.

引用

页码：303 / 306

页数：4

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