A CRITICAL-REVIEW OF THE TOXICOLOGY OF GLUTARALDEHYDE

被引：173

作者：

BEAUCHAMP, RO ^{[1
]}

STCLAIR, MBG ^{[1
]}

FENNELL, TR ^{[1
]}

CLARKE, DO ^{[1
]}

MORGAN, KT ^{[1
]}

KARI, FW ^{[1
]}

机构：

[1] NIEHS, RES TRIANGLE PK, NC 27709 USA

来源：

CRITICAL REVIEWS IN TOXICOLOGY | 1992年 / 22卷 / 3-4期

关键词：

GLUTARALDEHYDE REVIEW; HUMAN TOXICITY; ANIMAL TOXICITY; REPRODUCTIVE TOXICITY; GENOTOXICITY; METABOLISM; TOXICOKINETICS; PROTEIN MACROMOLECULES; ENVIRONMENT; HEALTH EFFECTS; ALDEHYDE COMPOSITION; USES;

D O I：

10.3109/10408449209145322

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Glutaraldehyde, a low molecular weight aldehyde, has been investigated for toxicity in humans and animals. Examination of this dialdehyde was indicated from previous studies with other aldehydes in which carcinogenicity of formaldehyde and toxicity of acetaldehyde and malonaldehyde have been disclosed. Information gaps concerning the actions of glutaraldehyde have been identified in this review and recommendations are suggested for additional short- and long-term studies. In particular, information regarding irritation of the respiratory tract, potential neurotoxicity, and developmental effects would assist in a complete hazard evaluation of glutaraldehyde. Further study related to disposition, metabolism, and reactions of glutaraldehyde may elucidate the mechanism of action.

引用

页码：143 / 174

页数：32

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