INHIBITORY EFFECTS OF CURCUMIN ON TUMOR INITIATION BY BENZO[A]PYRENE AND 7,12-DIMETHYLBENZ[A]ANTHRACENE

被引:248
作者
HUANG, MT [1 ]
WANG, ZY [1 ]
GEORGIADIS, CA [1 ]
LASKIN, JD [1 ]
CONNEY, AH [1 ]
机构
[1] UNIV MED & DENT NEW JERSEY, ROBERT WOOD JOHNSON MED SCH, DEPT ENVIRONM & COMMUNITY MED, PISCATAWAY, NJ 08854 USA
关键词
D O I
10.1093/carcin/13.11.2183
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The effects of topical administration of curcumin on the formation of benzo[a]pyrene (B[a]P)-DNA adducts and the tumorigenic activities of B[a]P and 7,12-dimethylbenz[a]anthracene (DMBA) in epidermis were evaluated in female CD-1 mice. Topical application of 3 or 10 mumol curcumin 5 min prior to the application of 20 nmol [H-3]B[a]P inhibited the formation of [H-3]B[a]P-DNA adducts in epidermis by 39 or 61% respectively. In a two-stage skin tumorigenesis model, topical application of 20 nmol B[a]P to the backs of mice once weekly for 10 weeks followed a week later by promotion with 15 nmol 12-0-tetradecanoylphorbol-13-acetate (TPA) twice weekly for 21 weeks resulted in the formation of 7.1 skin tumors per mouse, and 100% of the mice had tumors. In a parallel group of mice, in which the animals were treated with 3 or 10 mumol curcumin 5 min prior to each application of B[a]P, the number of tumors per mouse was decreased by 58 or 62% respectively. The percentage of tumor-bearing mice was decreased by 18-25%. In an additional study, topical application of 3 or 10 mumol curcumin 5 min prior to each application of 2 nmol DMBA once weekly for 10 weeks followed a week later by promotion with 15 nmol TPA twice weekly for 15 weeks decreased the number of tumors per mouse by 37 or 41% respectively.
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页码:2183 / 2186
页数:4
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