PRESERVED STRIATAL TYROSINE-HYDROXYLASE ACTIVITY, ASSESSED INVIVO, FOLLOWING NEONATAL HYPOXIA-ISCHEMIA

被引：11
作者：
BURKE, RE [1 ]
RECHES, A [1 ]
机构：
[1] HADASSAH UNIV HOSP,DEPT NEUROL,JERUSALEM,ISRAEL
来源：
DEVELOPMENTAL BRAIN RESEARCH | 1991年 / 61卷 / 02期
关键词：
STRIATUM; TYROSINE HYDROXYLASE; HYPOXIA-ISCHEMIA; NEONATAL; DOPAMINE; AUTORECEPTOR;
D O I：
10.1016/0165-3806(91)90143-7
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Previous in vitro studies have shown that biochemical indices of striatal dopaminergic systems are preserved following neonatal hypoxia-ischemia. There has been no previous assessment of these systems in vivo. Using the accumulation of striatal dopa following administration of a dopa decarboxylase inhibitor as an in vivo measure of tyrosine hydroxylase (TH) activity, we have found that baseline TH activity, and its regulation by both neuronal activity and presynaptic autoreceptors are also preserved following hypoxia-ischemia.
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页码：277 / 280
页数：4
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