Applications of circulating tumor cells for prostate cancer

被引：3

作者：

Cheng, Shirley ^{[1
]}

Chen, Jie-Fu ^{[1
,2
]}

Lu, Yi-Tsung ^{[1
,3
]}

Chung, Leland W. K. ^{[1
,2
,4
]}

Tseng, Hsian-Rong ^{[5
,6
]}

Posadas, Edwin M. ^{[1
,2
,7
]}

机构：

[1] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Urol Oncol Program, Los Angeles, CA 90048 USA

[2] Cedars Sinai Med Ctr, Dept Med, Div Hematol Oncol, Los Angeles, CA 90048 USA

[3] John H Stroger Hosp, Dept Internal Med, Chicago, IL USA

[4] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Canc Biol Program, Los Angeles, CA 90048 USA

[5] Univ Calif Los Angeles, Calif Nanosyst Inst, Los Angeles, CA USA

[6] Univ Calif Los Angeles, Dept Mol Pharmacol, Los Angeles, CA USA

[7] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Translat Oncol Program, Los Angeles, CA 90048 USA

来源：

ASIAN JOURNAL OF UROLOGY | 2016年 / 3卷 / 04期

关键词：

Prostate cancer; Circulating tumor cell; Biomarker; Liquid biopsy; Molecular oncology;

D O I：

10.1016/j.ajur.2016.09.004

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

One of the major challenges that clinicians face is in the difficulties of accurately monitoring disease progression. Prostate cancer is among these diseases and greatly affects the health of men globally. Circulating tumor cells (CTCs) are a rare population of cancer cells that have shed from the primary tumor and entered the peripheral circulation. Not until recently, clinical applications of CTCs have been limited to using enumeration as a prognostic tool in Oncology. However, advances in emerging CTC technologies point toward new applications that could revolutionize the field of prostate cancer. It is now possible to study CTCs as components of a liquid biopsy based on morphological phenotypes, biochemical analyses, and genomic profiling. These advances allow us to gain insight into the heterogeneity and dynamics of cancer biology and to further study the mechanisms behind the evolution of therapeutic resistance. These recent developments utilizing CTCs for clinical applications will greatly impact the future of prostate cancer research and pave the way towards personalized care for men. (C) 2016 Editorial Office of Asian Journal of Urology. Production and hosting by Elsevier B.V.

引用

页码：254 / 259

页数：6

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