PREPARATION AND ANTIMYCOTIC PROPERTIES OF DERIVATIVES OF 1-PHENETHYLIMIDAZOLE

被引：265

作者：

GODEFROI, EF

HEERES, J

VANCUTSE.J

JANSSEN, PAJ

机构：

[1] Research Laboraloria, Janssen Pharmaceutica n.v., Beerse, Belgium

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 05期

关键词：

D O I：

10.1021/jm00305a014

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of a large number of β-substituted 1-phenethylimidazoles is described. Many appropriately N-substituted 1-(β-aminophenethyl)imidazoles and cyclic ketals derived from 2-(1-imidazolyl)acetophenones were quite active against dermatophytes. However, 1-(β-benzyloxyphenethyl)imidazoles displayed potent, broad-spectrum activity, not only against dermatophytes but also against, yeast cells (Candida albicans) and gram-positive bacteria. © 1969, American Chemical Society. All rights reserved.

引用

页码：784 / &

共 8 条

[1]

BEILSTEIN FK, HANDBUCH ORGANISCHEN, V23, P37

[2] CYCLOALK-2-ENONES AND ALPHA,BETA,ALPHA',BETA'-CYCLOALKADIENONES .A. SYNTHESIS .B. ON DIRECTION OF BROMINATION OF 2-SUBSTITUTED CYCLOALKANONES AND THEIR KETALS [J].