Activity Of Vascular Disaggregation Effects On Erythrocytes In Patients With Abdominal Obesity And Dyslipidemia

A serious proportion of thromboses registered in the adult population occurs in patients with abdominal obesity and dyslipidemia. Their occurrence is usually associated with the development of severe vasopathy in these patients. In this regard, a great practical importance was the additional examination of patients with abdominal obesity and dyslipidemia. Of particular interest was their assessment of vascular disaggregation effects on erythrocytes. The aim of the work is to clarify the state of the disaggregation effects of blood vessels on erythrocytes in patients with abdominal obesity and dyslipidemia. 41 patients with abdominal obesity and dyslipidemia of the second adulthood were examined. Control is represented by 26 healthy volunteers of the second adult age. The work was carried out with the help of biochemical, hematological and statistical research methods. Patients under observation showed an increase in cholesterol in erythrocyte membranes, a decrease in phospholipids in them, and an increase in lipid peroxidation. In all patients, the growth of spontaneous aggregation of erythrocytes was found. This was accompanied by a decrease in vascular disaggregation control over red blood cells. In the course of the study, it became clear that the weakening of disaggregating vascular effects on erythrocytes is a consequence of metabolic abnormalities and excessive lipid peroxidation arising from abdominal obesity and dyslipidemia. Severe vasopathy arising in this contingent of patients is able to greatly increase the risk of thrombosis, often leading to disability or death.