High Case-Fatality Rate of Adults with Dengue Hemorrhagic Fever During An Outbreak In Non-Endemic Taiwan: Risk Factors For Dengue-Infected Elders

被引：21

作者：

Liu, Ching-Chuan ^{[1
]}

Huang, Kao-Jean ^{[2
]}

Huang, Mei-Chih ^{[3
]}

Lin, J. ^{[4
]}

Wang, S. ^{[5
]}

Liu, Jen-Jou ^{[8
]}

Tsai, Jih-Jin ^{[7
]}

Huang, Jyh-Hsiung ^{[9
]}

Lin, Yee-Shin ^{[2
]}

Liu, Hsiao-Sheng ^{[2
]}

Yeh, Trai-Ming ^{[6
,10
]}

Lei, Huan-Yao ^{[2
]}

机构：

[1] Natl Cheng Kung Univ, Coll Med, Dept Pediat, Tainan, Taiwan

[2] Natl Cheng Kung Univ, Coll Med, Dept Microbiol & Immunol, Tainan, Taiwan

[3] Natl Cheng Kung Univ, Coll Med, Dept Nursing, Tainan, Taiwan

[4] Natl Cheng Kung Univ, Coll Med, Dept Basic Med Sci, Tainan, Taiwan

[5] Natl Cheng Kung Univ, Coll Med, Dept Emergency Med, Tainan, Taiwan

[6] Natl Cheng Kung Univ, Coll Med, Dept Med Technol, Tainan, Taiwan

[7] Chang Gung Mem Hosp, Kaohsiung Med Ctr, Dept Infect Dis, Kaohsiung, Taiwan

[8] Kaohsiung Med Univ Hosp, Dept Internal Med, Kaohsiung, Taiwan

[9] Ctr Dis Control, Taipei, Taiwan

[10] Dept Hlth, Taipei, Taiwan

来源：

AMERICAN JOURNAL OF INFECTIOUS DISEASES | 2008年 / 4卷 / 01期

关键词：

Dengue disease; risk factors; elder; morbidity; mortality;

D O I：

10.3844/ajidsp.2008.10.17

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In 2002, a dengue outbreak occurred in Taiwan with 5336 confirmed cases, 242 DHF and 21 death, the case fatality rate reached 8.7% (21/242). The demographic data of these age-specific dengue patients showed that dengue virus infection caused symptom primarily occurred in adults. A comparative analysis of clinical and laboratory data for DF, DHF/DSS and fatal DSS found that high fatality from dengue infection was associated with the following patient conditions: (1) age above 55 years, (2) underlying diseases with hypertension, chronic renal insufficiency, or diabetes, (3) abnormal thrombocytopenia, APTT and PT prolongation, low hematocrit (<30%) and leukocytosis, (4) abnormal enlevation of AST, ALT and BUN. In a non-endemic area like Taiwan, dengue should be considered as an adult infectious disease and the dengue-infected elders will have higher morbidity or mortality.

引用

页码：10 / 17

页数：8

共 36 条

[1]

[Anonymous], 2003, EP B, V19, P16

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