INCREASE BY N-G-NITRO-L-ARGININE METHYL-ESTER (L-NAME) OF RESISTANCE TO VENOUS RETURN IN RATS

被引：56

作者：

WANG, YX ^{[1
]}

LIM, SL ^{[1
]}

PANG, CCY ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,FAC MED,DEPT PHARMACOL & THERAPEUT,VANCOUVER,BC V6T 1Z3,CANADA

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1995年 / 114卷 / 07期

关键词：

N-G-NITRO-L-ARGININE METHYL ESTER (L-NAME); NITRIC OXIDE; MEAN CIRCULATORY FILLING PRESSURE (MCFP); CARDIAC OUTPUT; TOTAL PERIPHERAL RESISTANCE; VENOUS RESISTANCE; CAPACITANCE VESSELS;

D O I：

10.1111/j.1476-5381.1995.tb13369.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1 The effects of the nitric oxide (NO) synthase inhibitor, N-G-nitro-L-arginine methyl ester (L-NAME), on mean circulatory filling pressure (MCFP), total peripheral resistance (TPR), cardiac output (CO) and resistance to venous return (R(v)) were studied in rats. 2 In conscious, unrestrained rats, L-NAME (0.5-16 mg kg(-1)) dose-dependently increased mean arterial pressure (MAP) but not MCFP, an inverse index of venous compliance, either in the absence of presence of the ganglionic blocker mecamylamine (10 mg kg(-1)). 3 In pentobarbitone-anaesthetized rats, L-NAME (2, 4, 8 mg kg(-1)) increased MAP and reduced CO in a dose-related manner but did not change MCFP. TPR (+84, +140 and +192%) as well as R(v) (+62, +72, +110%) were dose-dependently increased by L-NAME. 4 Our results show that L-NAME reduces CO by increasing arterial as well as venous resistances. L-NAME does not affect MCFP.

引用

页码：1454 / 1458

页数：5

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