DEHYDROEPIANDROSTERONE IS AN ANXIOLYTIC IN MICE ON THE PLUS-MAZE

被引：121

作者：

MELCHIOR, CL ^{[1
]}

RITZMANN, RF ^{[1
]}

机构：

[1] VET ADM MED CTR, BRENTWOOD DIV RES, LOS ANGELES, CA 90073 USA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1994年 / 47卷 / 03期

关键词：

DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE SULFATE; GABA; BENZODIAZEPINE; ANXIETY; MOTOR ACTIVITY; ETHANOL; MICE;

D O I：

10.1016/0091-3057(94)90140-6

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are neurosteroids that have been shown to interact with the GABA system. The present study examined the effects of these compounds in mice on motor activity and behavior in the elevated plus maze. Doses of 0.5 mg/kg and above of DHEA reduced motor activity. This effect was blocked by diazepam, RO15-1788, pentylenetetrazole (PTZ), and ethanol. Both DHEA and DHEAS showed anxiolytic activity in the plus maze test, with DHEA being effective over a very wide range of doses (5 mu g/kg to 1.0 mg/kg). Both RO15-1788 and PTZ blocked the anxiolytic effect of DHEA, there was no interaction with diazepam, and ethanol enhanced the anxiolytic effect of DHEA. At 1.0 mg/kg, DHEAS blocked the anxiolytic effect of ethanol. These results support the hypothesis that neurosteroids could be involved in the termination of a stress response.

引用

页码：437 / 441

页数：5

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[41] NICOTINIC RECEPTOR AGONISTS EXHIBIT ANXIOLYTIC-LIKE EFFECTS ON THE ELEVATED PLUS-MAZE TEST [J].

BRIONI, JD ;

ONEILL, AB ;

KIM, DJB ;

DECKER, MW .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 238 (01) :1-8

[42] ANXIOLYTIC PROFILES OF ALPRAZOLAM AND ETHANOL IN THE ELEVATED PLUS-MAZE TEST AND THE EARLY ACQUISITION OF SHUTTLEBOX AVOIDANCE [J].

PRUNELL, M ;

ESCORIHUELA, RM ;

FERNANDEZTERUEL, A ;

NUNEZ, JF ;

TOBENA, A .

PHARMACOLOGICAL RESEARCH, 1994, 29 (01) :37-46

[43] KAPPA-OPIOID AGONISTS PRODUCE ANXIOLYTIC-LIKE BEHAVIOR ON THE ELEVATED PLUS-MAZE [J].

PRIVETTE, TH ;

TERRIAN, DM .

PSYCHOPHARMACOLOGY, 1995, 118 (04) :444-450

[44] ANXIOGENIC EFFECT OF PHENYLETHYLAMINE AND AMPHETAMINE IN THE ELEVATED PLUS-MAZE IN MICE AND ITS ATTENUATION BY ETHANOL [J].

LAPIN, IP .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1993, 44 (01) :241-243

[45] Effects of weekly or daily exposure to the elevated plus-maze in male mice [J].

Espejo, EF .

BEHAVIOURAL BRAIN RESEARCH, 1997, 87 (02) :233-238

[46] Use of the elevated plus-maze test with opaque or transparent walls in the detection of mouse strain differences and the anxiolytic effects of diazepam [J].

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Feldon, Joram ;

Yee, Benjamin K. .

BEHAVIOURAL PHARMACOLOGY, 2006, 17 (01) :31-41

[47] Anxiogenic effect of sleep deprivation in the elevated plus-maze test in mice [J].

Regina H. Silva ;

Sonia R. Kameda ;

Rita C. Carvalho ;

André L. Takatsu-Coleman ;

Suzy T. Niigaki ;

Vanessa C. Abílio ;

Sergio Tufik ;

Roberto Frussa-Filho .

Psychopharmacology, 2004, 176 :115-122

[48] The involvement of adenosine receptors in the effect of dizocilpine on mice in the elevated plus-maze [J].

Fraser, CM ;

Fisher, A ;

Cooke, MJ ;

Thompson, ID ;

Stone, TW .

EUROPEAN NEUROPSYCHOPHARMACOLOGY, 1997, 7 (04) :267-273

[49] MK-801 induced amnesia for the elevated plus-maze in mice [J].

Hlinák, Z ;

Krejci, I .

BEHAVIOURAL BRAIN RESEARCH, 2002, 131 (1-2) :221-225

[50] Enhanced dorsolateral periaqueductal gray activity counteracts the anxiolytic response to midazolam on the elevated plus-maze Trial 2 in rats [J].

Bertoglio, LJ ;

Anzini, C ;

Lino-de-Oliveira, C ;

Carobrez, AP .

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