INTERPHASE CYTOGENETICS REVEALS SOMATIC PAIRING OF CHROMOSOME-17 CENTROMERES IN NORMAL HUMAN BRAIN-TISSUE, BUT NO TRISOMY-7 OR SEX-CHROMOSOME LOSS

被引：68
作者：
ARNOLDUS, EPJ
NOORDERMEER, IA
PETERS, ACB
RAAP, AK
VANDERPLOEG, M
机构：
来源：
CYTOGENETICS AND CELL GENETICS | 1991年 / 56卷 / 3-4期
关键词：
D O I：
10.1159/000133092
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Nuclei isolated from normal human brain tissue, collected from six autopsies, were hybridized with a panel of nine satellite DNA probes specific for the centromeric regions of chromosomes 1, 6, 7, 10, 11, 17, 18, and the X and Y chromosomes. The results did not confirm the recently reported trisomy 7 and loss of sex chromosomes observed in metaphases obtained from normal brain tissue after short-term cultures; however, cells of all six brains displayed somatic pairing of the chromosome 17 centromeres in approximately 50% of the nuclei.
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页码：214 / 216
页数：3
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