COINCIDENCE OF KLINEFELTERS SYNDROME AND SYSTEMIC LUPUS ERYTHEMATOSUS

被引：42

作者：

ORTIZNEU, C

LEROY, EC

机构：

[1] Columbia University, College of Physicians and Surgeons, New York, New York

[2] Columbia University, College of Physicians and Surgeons, New York, New York, 10032

来源：

ARTHRITIS AND RHEUMATISM | 1969年 / 12卷 / 03期

关键词：

D O I：

10.1002/art.1780120312

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The clinical features of 3 patients with Klinefelter's syndrome who had manifestations of systemic lupus erythematosus are reported. Two of them, young men with XXY karyotype, developed fever, arthritis, proteinuria, and positive LE cell tests; one of the two also had pleurisy with effusion, and the other, treated intermittently with diphenylhydantoin, developed a hemolytic anemia. The third patient, also with XXY karyotype, developed the nephrotic syndrome and was found to have a proliferative glomerulonephritis and a positive antinuclear factor test. The possible relationship of these patients to the “autoimmune” phenomena observed in chromosomal aberrations is discussed. Copyright © 1969 American College of Rheumatology

引用

页码：241 / &

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