GENE-EXPRESSION OF ENDOTHELIN RECEPTORS IN AORTIC-CELLS FROM CYCLOSPORINE-INDUCED HYPERTENSIVE RATS

被引：11

作者：

IWAI, J ^{[1
]}

KANAYAMA, Y ^{[1
]}

NEGORO, N ^{[1
]}

OKAMURA, M ^{[1
]}

TAKEDA, T ^{[1
]}

机构：

[1] OSAKA CITY UNIV,SCH MED,DEPT INTERNAL MED 1,ABENO KU,OSAKA 545,JAPAN

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1995年 / 22卷 / 6-7期

关键词：

CYCLOSPORINE; ENDOTHELIN; ET(A) RECEPTOR; ET(B) RECEPTOR; HYPERTENSION; RAT;

D O I：

10.1111/j.1440-1681.1995.tb02030.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. We examined preproendothelin-1, ET(A) and ET(B) receptor mRNA levels in aortic endothelial and smooth muscle cells from cyclosporine (CyA)-induced hypertensive rats using the reverse transcription polymerase chain reaction method, 2. Aortic endothelial preproendothelin-1 mRNA expression was about 1.5-fold higher, while that of ET(B) receptor mRNA was markedly decreased in CgA-treated rats compared with those in controls. 3. The expression of ET(A) receptor mRNA in smooth muscle cells from CyA-induced hypertensive rats was increased about two-fold over that in cells from control animals. 4. Thus, increased endothelial preproendothelin-1, and ET(A) receptor mRNA levels in smooth muscle cells, which are concomitant with the decrease in ET(B) receptor mRNA levels in endothelium, mag contribute to CyA-induced hypertension in rats.

引用

页码：404 / 409

页数：6

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