IMPORTANCE OF GLUCAGON IN MEDIATING EPINEPHRINE-INDUCED HYPERGLYCEMIA IN ALLOXAN-DIABETIC DOGS

被引:24
作者
PEREZ, G
KEMMER, FW
LICKLEY, HLA
VRANIC, M
机构
[1] UNIV TORONTO, DEPT MED, TORONTO M5S 1A1, ONTARIO, CANADA
[2] UNIV TORONTO, WOMENS COLL HOSP, TORONTO M5S 1A1, ONTARIO, CANADA
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1981年 / 241卷 / 04期
关键词
D O I
10.1152/ajpendo.1981.241.4.E328
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
In normal dogs epinephrine stimulates glucose production (Ra) independently of glucagon. To investigate the role of this interaction in diabetes, epinephrine (0.1 .mu.g .cntdot. kg-1 .cntdot. min-1) was infused for 90 min in 5 alloxan-diabetic dogs in the presence or absence of somatostatin (0.1 .mu.g .cntdot. kg-1 .cntdot. min-1). In response to epinephrine, glycemia rose by 40% reflecting a near maximal (122%) increase in Ra. Plasma glucagon (IRG) rose to 953 pg/ml; insulin (IRI) increased minimally. When somatostatin was infused with epinephrine to prevent the rise of IRG and IRI, there was only a marginal increase of glucose concentration (12%) and production (38%). The effect of somatostatin was reversed by infusing glucagon (10 ng .cntdot. kg-1 .cntdot. min-1) together with epinephrine and somatostatin into 5 additional alloxan-diabetic dogs. Increments in IRG, glycemia and Ra were fully reestablished. A 100% free fatty acid increase was observed in all 3 groups, indicating that the lipolytic effect of epinephrine was independent of glucagon. In diabetic dogs, in contrast to normal dogs epinephrine induced a marked and prolonged increase in glucose concentration and production mostly through a stimulation of IRG secretion.
引用
收藏
页码:E328 / E335
页数:8
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