(R)-ALPHA-METHYLHISTAMINE INHIBITS ETHANOL-INDUCED GASTRIC-LESIONS IN THE RAT - INVOLVEMENT OF HISTAMINE H-3 RECEPTORS

被引:22
作者
MORINI, G
GRANDI, D
BERTACCINI, G
机构
[1] UNIV PARMA,INST PHARMACOL,I-43100 PARMA,ITALY
[2] UNIV PARMA,INST ANAT,I-43100 PARMA,ITALY
关键词
(R)-ALPHA-METHYLHISTAMINE; ETHANOL; GASTRIC LESION; RAT; THIOPERAMIDE; FAMOTIDINE; INDOMETHACIN;
D O I
10.1159/000201234
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
This study examined the gastroprotective effect of (R)-alpha-methylhistamine (MHA), a selective agonist of histamine H-3 receptors, Gastric lesions were induced in the rat by administering absolute ethanol in a volume of 1 ml. Stomachs were removed 1 h later and lesions evaluated both macroscopically and histologically. MHA dose-dependently inhibited ethanol-induced lesions in the range 1-100 mg/kg both by the intragastric and intraperitoneal route. Histological findings indicated that the number of mucous granules in surface and neck cells was increased and the process of reepithelialization was rapidly promoted by MHA. Thioperamide, at 10 mg/kg, inhibited the protective effect of 10 but not of 100 mg/kg of MHA. Larger doses of thioperamide could not be tested because of an interaction with ethanol causing central nervous system effects. Famotidine and indomethacin pretreatment only partially counteracted the MHA effect. The results indicate that MHA is highly effective in preventing ethanol-induced lesions but the exact mechanism is still uncertain.
引用
收藏
页码:145 / 152
页数:8
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