ABSOLUTE STEREOCHEMISTRY OF AMPHIDINOLIDE-B

被引：45

作者：

ISHIBASHI, M ^{[1
]}

ISHIYAMA, H ^{[1
]}

KOBAYASHI, J ^{[1
]}

机构：

[1] HOKKAIDO UNIV,FAC PHARMACEUT SCI,SAPPORO,HOKKAIDO 060,JAPAN

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 44期

关键词：

D O I：

10.1016/0040-4039(94)88292-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The absolute stereochemistry of amphidinolide B (1), a potent cytotoxic 26-membered macrolide isolated from the cultured marine dinoflagellate Amphidinium sp., has been established as 8S, 9S, 11R, 16R, 18S, 21R, 22S, 23R, and 25S, on the basis of enantiospecific synthesis of a degradation product (2).

引用

页码：8241 / 8242

页数：2

共 6 条

[1] THE STRUCTURES OF AMPHIDINOLIDE-B ISOMERS - STRONGLY CYTOTOXIC MACROLIDES PRODUCED BY A FREE-SWIMMING DINOFLAGELLATE, AMPHIDINIUM SP [J].

BAUER, I ;

MARANDA, L ;

SHIMIZU, Y ;

PETERSON, RW ;

CORNELL, L ;

STEINER, JR ;

CLARDY, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (06) :2657-2658

[2] SYNTHESIS OF THE C5-C9 FRAGMENT OF THE POLYPROPIONATE UNIT OF THE GEODIAMOLIDES AND JASPAMIDE [J].

CHIARELLO, J ;

JOULLIE, MM .

SYNTHETIC COMMUNICATIONS, 1989, 19 (19) :3379-3383

[3] EFFICIENT SYNTHESES OF GEODIAMOLIDE-A AND JASPAMIDE, CYTOTOXIC AND ANTIFUNGAL CYCLIC DEPSIPEPTIDES OF MARINE SPONGE ORIGIN [J].

IMAEDA, T ;

HAMADA, Y ;

SHIOIRI, T .

TETRAHEDRON LETTERS, 1994, 35 (04) :591-594

[4] AMPHIDINOLIDE-B, A NOVEL MACROLIDE WITH POTENT ANTINEOPLASTIC ACTIVITY FROM THE MARINE DINOFLAGELLATE AMPHIDINIUM SP [J].

ISHIBASHI, M ;

OHIZUMI, Y ;

HAMASHIMA, M ;

NAKAMURA, H ;

HIRATA, Y ;

SASAKI, T ;

KOBAYASHI, J .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1987, (14) :1127-1129

[5] CYTO-TOXIC MACROLIDES FROM A CULTURED MARINE DINOFLAGELLATE OF THE GENUS AMPHIDINIUM [J].

KOBAYASHI, J ;

ISHIBASHI, M ;

NAKAMURA, H ;

OHIZUMI, Y ;

YAMASU, T ;

HIRATA, Y ;

SASAKI, T ;

OHTA, T ;

NOZOE, S .

JOURNAL OF NATURAL PRODUCTS, 1989, 52 (05) :1036-1041

[6] AMPHIDINOLIDE-L, A NEW CYTOTOXIC 27-MEMBERED MACROLIDE FROM THE CULTURED DINOFLAGELLATE AMPHIDINIUM SP [J].

TSUDA, M ;

SASAKI, T ;

KOBAYASHI, J .

JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (13) :3734-3737

← 1 →