SIGNIFICANCE OF IMMUNOHISTOCHEMICAL C-ERBB-2 PRODUCT LOCALIZATION PATTERN FOR PROGNOSIS OF PRIMARY HUMAN BREAST-CANCER

被引：16

作者：

ZSCHIESCHE, W ^{[1
]}

SCHONBORN, I ^{[1
]}

MINGUILLON, C ^{[1
]}

SPITZER, E ^{[1
]}

机构：

[1] FREE UNIV BERLIN,UNIV HOSP RUDOLF VIRCHOW,DEPT GYNECOL,D-14059 BERLIN,GERMANY

来源：

CANCER LETTERS | 1994年 / 81卷 / 01期

关键词：

C-ERBB-2; BREAST CANCER; IMMUNOHISTOCHEMISTRY; PROGNOSIS;

D O I：

10.1016/0304-3835(94)90169-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Concerning immunohistochemistry of the c-erbB-2 receptor in human mammary carcinoma, membranous immunostaining of tumor cells has been generally considered as a potential risk factor for early recurrence, whereas cytoplasmic reactivity has been neglected. An archival study on 463 patients with primary breast cancers demonstrates that cytoplasmic localization of p185 is significantly correlated with high estrogen and progesterone receptor levels, low histological grade and a low proliferating tumor cell fraction. In accordance with these data, patients bearing mammary carcinomas with cytoplasmic localization of p185 reactivity have a significant better overall survival than those with membranous immunostaining.

引用

页码：89 / 94

页数：6

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