THE HUMAN NME2 GENE LIES WITHIN 18KB OF NMEI IN CHROMOSOME-17

被引：21
作者：
CHANDRASEKHARAPPA, SC
GROSS, LA
KING, SE
COLLINS, FS
机构：
[1] UNIV MICHIGAN, CTR HUMAN GENOME, 1150 W MED CTR DR, ROOM 4570 MSRB 22, ANN ARBOR, MI 48109 USA
[2] UNIV MICHIGAN, MED CTR, DEPT INTERNAL MED, ANN ARBOR, MI 48109 USA
[3] UNIV MICHIGAN, MED CTR, HOWARD HUGHES MED INST, ANN ARBOR, MI 48109 USA
[4] UNIV MICHIGAN, MED CTR, DEPT HUMAN GENET, ANN ARBOR, MI 48109 USA
来源：
GENES CHROMOSOMES & CANCER | 1993年 / 6卷 / 04期
关键词：
D O I：
10.1002/gcc.2870060411
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The NME1 gene, localized to human chromosome 17 at q22, shows reduced expression in tumors of high metastatic potential. A homologous gene, NME2, with similar reduced expression in breast carcinoma, has recently been reported. We have isolated and characterized five yeast artificial chromosome (YAC) clones and three cosmid clones that contain both genes, demonstrating that the NME2 gene is also located on chromosome 17 and is separated by not more than 18 kb from the NME1 gene. The two putative tumor suppressor genes, encoding the two polypeptide chains of nucleoside diphosphate (NDP) kinase, are thus quite close to each other on chromosome 17, indicating that they may well have arisen by a tandem duplication. Both genes now appear to be excluded as candidates for the early-onset breast cancer (BRCA1) locus.
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页码：245 / 248
页数：4
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